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POCASI

(POlarimetric Controlled Annulation for Selective Imaging in scattering biological tissue)

Standard optical systems show good performances when visualizing objects in transparent or low scattering media. New challenges have appeared over the last years, such as the extraction of images from noisy background (polarimetric or spectroscopic imaging, ballistic/selective laser amplification…), real time correction in turbulent media (adaptive optics), or discrimination of complex objects (tomography, multi-photonic/non-linear imaging…). These efforts have given rise to several modern high-resolution imaging techniques in biological tissue, with the advantage of being non-ionizing, non-invasive, with low cost and having a large field of application in the biomedical and biological field. However, a major difficulty is to get rid of the tissue light-scattering, in order to optimize the contrast and spatial resolution. In this project we propose to apply a novel selective cancellation principle of light-scattering through the control of light polarimetric properties.

The principles underlying selective polarimetric cancellation were recently published and their applicative consequences have been patented. First data have validated the principles, such as extinction of bulk scattering in low scattering media (see figure).

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We will explore two applications : breast imaging and (functional) imaging of the cerebral cortex. This pluri-disciplinar program requires collaboration from physicists, neuroscientists, medical staff and industrials. The development of a laboratory prototype has been started, mainly devoted to preliminary tests and applications. In this draft we propose to join several laboratories together as well as industrial partners; this will give the project another and more applied dimension to investigate the feasibility of the technique within the context of specific biomedical and biological situations (breast imaging and functional imaging of the cortex).  Specific application prototypes will be developed and will be turned into “systems”, on the basis of a key expertise at Institut Fresnel in Marseilles.

The project has been the label of the French “Pôle de Compétitivité” “Photonics : complex system of optics and imaging”.

Investigator : Prof. C. DEUMIE, Central School of Engineering and Institut Fresnel (UMR 6133 CNRS).

 

 

 

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